- 20 Patients under long-term (>3 months) Low Dose Aspirin (LDA) treatment
- Duration of the study – 4 weeks
- Study drug – 150mg Zinc Carnosine for 4 weeks
Clinical Applications and Efficacy
The tissue supportive and cytoprotective effects of Zinc Carnosine has been evaluated in numerous clinical trials. Zinc Carnosine has demonstrated gastroprotectant and wound healing effect in conditions like gastritis, NSAID induced gastritis, gastric ulcers and H.pylori infections.
NSAID Induced Enteritis
Nonsteroidal anti-inflammatory drug (NSAID) prescriptions are among the most common in the world. However NSAID use is linked to a higher risk of upper gastrointestinal mucosal injury, which can lead to peptic ulcers and/or bleeding. Zinc Carnosine has proven efficacy against NSAID-induced small-bowel injury without reducing gastric pH.
Co-administration of Zinc Carnosine is Effective Against Small-bowel Mucosal Injury. Associated With Long-term NSAID or Aspirin Therapy.
Zinc Carnosine along with NSAIDs effective for reducing small bowel mucosal injury associated with NSAID
BMC Gastroenterology 2013, 13:108
Peptic Ulcers
Studies have demonstrated that Zinc Carnosine is effective at reducing symptoms in patients with ulcers and promote healing of the damaged area. Zinc Carnosine aids in rapid healing of ulcers irrespective of the underlying cause such as gastritis, Helicobacter pylori infection, endoscopic submucosal dissection (ESD), or concurrent pharmacological treatment.
Effective at reducing the Symptoms Associated With Ulcers, While Promoting Healing of the Gastric Ulcers
- Double-blind multicenter trial
- Compared the efficacy of Zinc Carnosine 75mg twice daily in gastric ulcers
- Duration of the study 8 weeks
Zinc Carnosine along with NSAIDs effective for reducing small bowel mucosal injury associated with NSAID
BMC Gastroenterology 2013, 13:108
H Pylori Eradiction
Zinc Carnosine inhibits the growth of H. pylori because of the interference of zinc with urease activity and inhibits the inflammatory responses in H. pylori.
Effective Adjuvant with Triple Therapy for H Pylori Eradiction
- 66 dyspeptic patients with H.pylori
- Grp I- Lansoprazole, Amoxicillin, and Clarithromycin (LAC)
- Grp II- Lansoprazole, Amoxicillin, and Clarithromycin + Zinc Carnosine (LACZ)
- Duration of study – 7 days
- Treatment efficacy significantly improved by the addition of Zinc Carnosine
- Significant anti H. pylori effect when combined with triple therapy for H pylori.
Coadministration with PPIs
Studies have demonstrated acceleration of mucosal healing after endoscopic procedures when Zinc Carnosine has been coadminsitered with proton pump inhibitors. The combination reduces the rate of complications (e.g bleeding, stenosis) and post-procedure symptoms, significantly improving outcomes and patient quality of life.
Zinc Carnosine local application effectively prevents and treats cancer treatment induced oral mucosal injury
- One hundred sixty-three patients with ulcers induced by endoscopic submucosol dissection (ESD)
- Grp I- lansoprozole 30 mg
- Grp II- lansoprozole 30 mg + Zinc Carnosine 75 mg twice daily
- Duration of study – 2 days
Zinc Carnosine along with NSAIDs effective for reducing small bowel mucosal injury associated with NSAID
BMC Gastroenterology 2013, 13:108
Oral Mucositis
Zinc L-carnosine oral and local administration can prevent and treat oral mucositis in cancer patients undergoing radiation or high-dose chemotherapy.
Zinc Carnosine Reduces Oral Mucosal Damage Caused by Radiotherapy or Chemotherapy in Cancer Patients
Zinc Carnosine local application effectively prevents and treats cancer treatment induced oral mucosal injury.
- Evaluation of Preventive and therapeutic effects of Zinc Carnosine oral rinse
- 423 cancer patients undergoing different treatment approaches
- Duration 4 weeks
Local application of Zinc Carnosine effectively improves oral mucosal injury in patients with symptoms of oral mucosal injury as a result of cancer treatment.
Annals of Oncology 24 (Supplement 9): ix66-ix99, 2013
Pressure Sores/ Decubitus Ulcers
Zinc Carnosine is Effective and Well-tolerated in 8-week Treatment of Pressure Ulcers
- Evaluation of preventive and therapeutic effects of Zinc Carnosine oral rinse
- 423 cancer patients undergoing different treatment approaches
- Duration 4 weeks
Zinc Carnosine oral treatment is effective as a treatment for chronic pressure ulcers.
Biol Elem Res 2014 Jun;158(3):280-8