Zinobliss Gel

Zinobliss Gel
Heals mouth ulcers, heals pain…
Zinc Carnosine 2% w/w
Lignocaine HCL IP 2% w/w Mouth Ulcer Gel

Thanks to Zinobliss Gel’s unique combination of Zinc Carnosine +Lignocaine, with the chelate technology, Zinc Carnosine stays at the ulcer site to heal while lignocaine assists in mouth ulcer pain.

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Why Zinobliss?
  • Unique Anti-Ulcer Property
  • Cytoprotective and Tissue Repairing Action
  • Anti-Inflammatory Property
  • Dual Benefit of Tissue Healing and Pain Relief
  • Supportive Therapy for Radiation and Chemotherapy Induced Stomatitis
  • Effective Relief for Mouth Ulcers
Clinical Indications
Zinobliss Gel is effective in healing sulcers in the following conditions –
  • Oral Mucositis
  • Stomatitis
  • Chemotherapy / Radiotherapy induced oral ulcer
  • Aphthous Stomatitis (Canker sore)
  • Recurrent Aphthous Stomatitis
  • Oral Lichenplanus
Zinosine - Mode of Action
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Clinical Efficacy
Zinc Carnosine in Oral Stomatitis
  • Randomised controlled study studying effect of zinc L-carnosine on radiochemotherapy-induced oral mucositis, pain, xerostomia and taste disturbance in patients with head and neck cancer.
  • Zinc Carnosine reduced the risk of oral mucositis by 90.6%.
  • The incidence rates of mucositis, pain, xerostomia and taste disturbance were all markedly lower in Zinc Carnosine group than in control.
  • Use of analgesics was significantly (p < 0.003) less frequent and the amount of food intake was significantly (p < 0.002) higher in Zinc Carnosine group than control.
Zinc Carnosine in Gingivostomatitis
  • High effectiveness of Zinc Carnosine suspension local application was demonstrated in patients with severe gingivostomatitis.
  • Zinc Carnosine – sodium alginate as a specific treatment for severe gingivostomatitis was administered to 15 patients who had developed inflammation while on chemotherapy.
  • Very high utility of the application was demonstrated and the response was classified as excellent in 10 patients and good in 5 patients.
  • The mechanism of the beneficial effect of Zinc Carnosine in treatment of severe gingivostomatitis and ulcers was considered to involve the mucosal protective effect, free radical scavenging activity and tissue repair promoting action of Zinc Carnosine.
Direction for Use

Take a quantity sufficient enough to coat the ulcers and spread it uniformly over the affected sites. The administration can be repeated 3 or 4 times daily or as directed by the Physician.

Possible side efffects

The Zinc Carnosine in ZINOBLISS has no known side effects and is well tolerated and no Zinc accumulation is noted following repeated administration. The Lignocaine in ZINOBLISS may cause temporary redness, stinging and swelling at the application site. If these side effects persist or worsen, discontinue use and notify your physician.

FAQs – Patient Information
What is Zinobliss Gel?

Zinobliss is an oral gel containing Zinc Carnosine and lignocaine, which in combination help in healing mouth ulcers and relieving ulcer pain

What are mouth ulcers?

Mouth Ulcers are lesions (injuries) occurring inside the mouth which are often painful and irritating to the skin.

What are the symptoms of mouth ulcers?

Mouth ulcers have one-point pain at a particular point, and also painful tender areas.

How does mouth ulcer impact you?

Mouth ulcers often hamper the overall health of the mouth. Since mouth ulcers are painful, you might have difficulty in swallowing, speaking and even drinking. Many times, depending on the severity of ulcers, it might be painful even when you are not consuming anything.

What are the causes of mouth ulcers?

There are many factors that can trigger the formation of ulcers. These include:

  • Poor oral health hygiene
  • Due to several external conditions such as:
    • Ulcers due to cancer/chemotherapy
    • Ulcers due to radiation therapy in cancer
    • Canker sores or stomatitis
  • Food sensitivities to acidic foods like strawberries, and other trigger foods like chocolate and coffeeLack of few essential vitamins
What care should be taken while using Zinobliss Gel?

Zinobliss contains Zinc Carnosine and lignocaine and some part of it may be ingested while application at the ulcer site. For this reason, food should not be ingested 60 mins following it’s use.

Are there any side effects of Zinobliss gel?

Zinc carnosine in Zinobliss has no known side effects. In rare cases, the lignocaine in Zinobliss may cause temporary redness, stinging or swelling in which cases the treatment should be discontinued and your physician should be notified.

How to apply Zinobliss Gel?

Take little quantity (enough to cover the area of ulcers) and spread it uniformly over the affected area. This can be applied 3-4 times daily or as the physician suggests.

FAQs – Physician’s Information
Does Zinobliss help in healing of ulcer as well as provide symptomatic relief from pain?

Yes, Zinobliss helps in healing of ulcer and provide symptomatic relief from pain. Zinc Carnosine in Zinobliss helps in healing of ulcer and Lignocaine in Zinobliss provides symptomatic relief from pain.

How does Zinobliss help in healing of ulcer in the mouth?

Zinc Carnosine in Zinobliss increases production of Insulin like growth factor-1(IGF-1) ensuring epithelial wound healing in the mouth.

Does Zinobliss treat oral lichen planus?

Lichen planus is a inflammatory condition of mucosal lining of buccal cavity. Zinc Carnosine in Zinobliss controls inflammation by inhibiting pro—inflammatory Cytokines i.e. Interleukin-8 and TNF-alpha . and Lignocaine in Zinobliss provides symptomatic relief from pain.As a result, Zinobliss is very effective for treating Lichen planus.

Does conventional mouth ulcer gel help in healing of ulcer in the mouth?

No, Conventional mouth ulcer gel does not help in healing of ulcer in the mouth, whatever ulcer healing takes place i.e. because of body’s own defence mechanism.

Will Zinobliss help in healing of oral ulcer faster than conventional mouth ulcer gel?

Yes Zinobliss helps in healing of oral ulcer faster than conventional mouth ulcer gel. As Zinc Carnosine in Zinobliss scavenges hypochlorite which is responsible delayed wound healing.

Is Zinobliss effective in radiation induced Mucositis?

Zinobliss is highly effective in reducing the incidence of oral mucositis. There was a reduction of 86.7% in oral mucositis who underwent radiotherapy.

Is there any side effect of Zinobliss like Staining of teeth, Alteration of taste, Calculus formation, Oral irritation, Burning sensation and suppressing of Immune system?

No, Zinobliss does not cause Staining of teeth, Alteration of taste, Calculus formation, Oral irritation, Burning sensation and Suppressing of Immune system unlike Chlorhexadine and Trimcinolone.

Can Zinobliss be recommended to Children or Young people under 16 yrs of age?

Zinobliss can be recommended to Children or young people under 16 yrs of age unlike Choline salicylate.

How to use Zinobliss?

The lami tube of Zinobliss to be pressed to bring out sufficient quantity on tip of the index finger and to be rubbed gently on the affected irritated area . To be applied 3 times a day.

Is there any published clinical trial on Zinc Carnosine in oral mucositis and Chemo and radio therapy induced ulcer?

Yes, Clinical trial was conducted on 32 patients with head and neck cancer who underwent radiotherapy and Zinc Carnosine was found highly effective in reducing the incidence of Mucositis , pain , xerostomia and taste disturbance due to radio and chemotherapy. The said clinical trial was published in International Journal of Cancer in 2010.

Is there any chance of destroying of Zinc Carnosine in buccal cavity?

No, Zinc Carnosine in Zinobliss does not destroy in the buccal cavity due to its chelation.

Can Zinc carnosine wash out after application at ulcer site due to secretion of saliva in the buccal cavity?

Due to its Polymeric character, Zinc Carnosine does not dissociate from the ulcer site rather it sticks to the ulcer site for a longer period of time thus helps in faster healing of ulcer.